Jun 24 2008
In Woman Or Merry Man With Sexual of the Shingles, Aciclovir does Not Prevent Aquisition HIV
Aciclovir, Antivirusnoe medicine, does not reduce the come HIV-1 inn woman or man, who prepare a shingles sexual, which has a coition with man, according to author of the Article released in June 20, 2008 inn Lancet.
The Simplex virus of the herpes type-2 infections (HSV-2), most general reason of the shingles sexual, is bound two upon the body three-pack the accumulated risk to infections HIV-1. To pinch to define the nature to this assotiations, Dr. Connie Celum, University Washington, Seattle, USA, and colleagues, studied effects of the suppression HSV-2 immediately after aciclovir on HIV-1. This be made using negative HIV-, positive women(woman)s HSV-2 in Africa and subject, who have a screwing with man (MSM) with places in Peru and army.
In mixed, operated the agency of phase III test, participants be nominated to be control 400mg aciclovir (1,637 patients) or (1,640 patients) during 12-18 months. Followups Were Executed monthly to study the distribution a medicine dissection, execute the counsel of the adherence, count of the pill (itself registered), and reduction counsel of the risk. Each three months, examinations sexual and test retrovirus were executed. The Tested results were an infection HIV-1 and and canker sexual HSV-2.
The Participants were 1,358 womans and 1,814 MSM comprised of interpretation: 1,581 inn group aciclovir and 1,591 in controlling gruppe. incidence HIV-1 was not vastly another between group. This before-mentioned, incidence gentical cankers reducted to 47% in group aciclovir, and 65% cankers sexual confirmed two be due to HSV-2. Was Not not any serious disadvantage actuality in recorded drug.
In conclusion, authors indicate that aciclovir has an no influence in agent of the issue HIV-1 in this population. “Our results show that repressing therapy with standard dose aciclovir not efficient in reduction of aquisition HIV-1 in HSV-2 seropositive woman and MSM. The New strategies - it is necessary to announce the interaction between HSV-2 and HIV-1.” Additionally, speak, these futher studies be required to have existence executed too install independently this defect to efficiency is becoming to absorptions medicine and metabolism, clinical answer of the cankers sexual in medicament, or firm answer firm sexual after HSV-2 will be actuated.
The Professor Ronald Gray and Weaver Professor Maria, John histrion University, metropolis, MD, USA, accompanying commentary inn which they argue if management sexual sent infection must be advanced for prevention HIV in negative population HIV. “Thomas Henry Huxley commented that ‘ big tragedy of the science - a murder of the beautiful hypothesis by ugly fact.’ The Time to revalue the hypothesis and to adjust the policy of the prevention narrative.”
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